2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-G0016
    N-Acetyl dapsone
    N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688). Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities.
    N-Acetyl dapsone
  • HY-15793A
    Trans (2,3)-Dihydrotetrabenazine
    Trans (2,3)-Dihydrotetrabenazine ((2R,3R,11bR)-rel-Dihydrotetrabenazine), a metabolite of Tetrabenazine, shows remarkable inhibition activity on vesicular monoamine transporter (VMAT2).
    Trans (2,3)-Dihydrotetrabenazine
  • HY-114461B
    (3S,17S)-FD-895
    (3S,17S)-FD-895 is a FD-895 analogue. (3S,17S)-FD-895 can inhibit the growth of HCT116 cells and has splicing regulation activity. (3S,17S)-FD-895 can be used in the study of cancer.
    (3S,17S)-FD-895
  • HY-144203S
    Trospium EP impurity C-d8 chloride
    Trospium EP impurity C-d8 (chloride) is the deuterium labeled Trospium EP impurity C chloride.
    Trospium EP impurity C-d<sub>8</sub> chloride
  • HY-133787R
    Levofloxacin N-oxide (Standard)
    Levofloxacin N-oxide (Standard) is the analytical standard of Levofloxacin N-oxide. This product is intended for research and analytical applications. Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria.
    Levofloxacin N-oxide (Standard)
  • HY-W585893
    Endrin ketone
    Endrin ketone is an Endrin (HY-W585893) degradation product. Endrin is a carcinogen.
    Endrin ketone
  • HY-N15575
    Rhamnitol
    Rhamnitol is the reduction product of L-rhamnose that can be found in the metabolism of ingested rhamnose in the body. Rhamnitol is promising for research of intestinal permeability assessment and carbohydrate metabolism.
    Rhamnitol
  • HY-G0001S
    Lurasidone Metabolite 14283-d8
    Lurasidone Metabolite 14283-d8 is the deuterium labeled Lurasidone Metabolite 14283, which is a metabolite of Lurasidone.
    Lurasidone Metabolite 14283-d<sub>8</sub>
  • HY-32350S
    Ercalcitriol-13C,d3
    Ercalcitriol-13C,d3 is the 13C- and deuterium labeled Ercalcitriol. Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.
    Ercalcitriol-<sup>13</sup>C,d<sub>3</sub>
  • HY-101108S
    Tazarotenic acid-d6
    Tazarotenic acid-d6 is deuterium labeled Tazarotenic acid. Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.
    Tazarotenic acid-d<sub>6</sub>
  • HY-131283
    8-Demethyl Ivabradine
    8-Demethyl Ivabradine is a metabolite of Ivabradine. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.
    8-Demethyl Ivabradine
  • HY-131281
    Ivabradine impurity 1
    Ivabradine impurity 1 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.
    Ivabradine impurity 1
  • HY-138149
    2-epi-Abamectin
    2-epi-Abamectin is a degradation product of Abamectin. It is toxic to the two-spotted spider mite in a contact assay with an LC50 value of 4 ppm, which is approximately 100-fold less potent than abamectin.
    2-epi-Abamectin
  • HY-173577
    Benazepril acyl-β-D-glucuronide
    Benazepril acyl-β-D-glucuronide is a Glucuronide metabolite.
    Benazepril acyl-β-D-glucuronide
  • HY-W748688
    N4-Acetylsulfamethoxazole-13C6
    N4-Acetylsulfamethoxazole-13C6 (Acetylsulfamethoxazole-13C6) is the 13C-labeled N4-Acetylsulfamethoxazole (HY-W013266). N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is a metabolite of?Sulfamethoxazole (HY-B0322). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic, used for bacterial infections.
    N4-Acetylsulfamethoxazole-<sup>13</sup>C<sub>6</sub>
  • HY-17366AR
    Clozapine N-oxide dihydrochloride (Standard)
    Clozapine N-oxide (dihydrochloride) (Standard) is the analytical standard of Clozapine N-oxide (dihydrochloride). This product is intended for research and analytical applications. Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
    Clozapine N-oxide dihydrochloride (Standard)
  • HY-133794R
    Dasatinib N-oxide (Standard)
    L-Ascorbic acid (GMP Like) (Standard) is the analytical standard of L-Ascorbic acid (GMP Like). This product is intended for research and analytical applications. L-Ascorbic acid (GMP Like) is the GMP Like class L-Ascorbic acid (HY-B0166). L-Ascorbic acid (L-Ascorbate, Vitamin C), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells.
    Dasatinib N-oxide (Standard)
  • HY-I0736S
    Isonicotinic acid-d4
    		98.12%
    Isonicotinic acid-d4 is the deuterium labeled Isonicotinic acid (HY-I0736). Isonicotinic acid is an Isoniazid (HY-B0329) metabolite. The Isonicotinic acid derivative Enisamium inhibits the replication of multiple subtypes of influenza A virus.
    Isonicotinic acid-d<sub>4</sub>
  • HY-143970S
    Ivabradine impurity 7-d6
    Ivabradine impurity 7-d6 is the deuterium labeled Ivabradine impurity 7.
    Ivabradine impurity 7-d<sub>6</sub>
  • HY-136344
    Simvastatin Acyl-β-D-glucuronide
    Simvastatin Acyl-β-D-glucuronide is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
    Simvastatin Acyl-β-D-glucuronide
Cat. No. Product Name / Synonyms Application Reactivity